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Besides, roFPs under physiological conditions are only sensitive to oxidative stress but not to any reductive stress because they completely transition to a fully reduced state once in the cytosol

While we have shown that plasma proteomic organ aging models are distinct from previous proteomics models, clinical chemistry-based models and imaging-based models, future studies should assess how proteomic organ aging relates to other molecular measures of aging and disease such as methylation aging clocks and disease-specific prediction models

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Insights from these studies may pave the way for new formulations and delivery methods that optimize results

Release of these proteins including cytochrome c, s econd m itochondria-derived a ctivator of c aspase (Smac), apoptosis inducing factor (AIF) and endonuclease G have been extensively studied in the context of apoptotic cell death, and it is recognized that the mechanisms of their release may not be identical in all cases