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Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression

Compared with healthy controls, patient-derived monocytes showed significantly increased expression of SLC25A33 and pro-inflammatory cytokines, while SLC25A22 and SLC25A37 did not show significant changes in expression (Fig

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Moreover, ALC and NAC mitigate Nf-kB overactivated signal, attenuating NLRP3 inflammasome pathway (IL1 and IL18) and decreasing serum TNF-alpha, IL-1, IL-6 levels, and PCR [161, 202, 217], thereby their immunomodulatory activities [161, 227, 228], and protecting against cytokine storms [82, 135, 218]