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A.GhafooriH.FarahmandZ.MohammadKhaniE.VakhshitehF.et al (2018)

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Although PBPK model-based predictions of DDIs are well-established, research on predicting HDIs remains relatively limited

Therefore, for a ROS-mediated therapeutic approach to be effective, this therapy must limit ROS production when ROS would induce proliferation, and it must promote ROS production when ROS would induce apoptosis