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This work was supported by the Wilmot Cancer Institute Predoctoral Fellowship (G.A.), Wilmot Cancer Institute Pilot Funding (I.S.H.), the American Association for Cancer Research and Breast Cancer Research Foundation (20-20-26-HARR) (I.S.H.), Breast Cancer Coalition of Rochester (I.S.H.), a Sir Henry Wellcome Postdoctoral Fellowship (M.E.K.), and a FNR-CORE grant C21/BM/15796788 (D.B.), and NIH grants R01CA269813 (I.S.H.), R37CA230042 (G.M.D), R24AA022057 (V.V.), R01AA028859 (Y.C.), AI150698 (J.M.), K01CA240533-01A1 (C.L.C.), and R01AR078000 (R.T.D.)

Taking magnesium with meals can improve tolerance and reduce potential digestive side effects

EGCG also protects against astrogliosis and maintains blood-brain barrier integrity, reducing peripheral immune cell infiltration

However, the review identified crucial methodological limitations, including the lack of rigorous standardization of the extracts, high phytochemical variability, and weaknesses in experimental designs, which may increase the risk of bias