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In clinical practice, combination approaches are increasingly common

This is supported by the RCT studies which showed a similar number of AEs in the placebo group to the treatment groups (Sandborn et al .,

Kosuru et al., 2016) able to protect neurons against neuroinflammation due to the inhibition of ROS production (Shin et al., 2010)

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In vivo , findings demonstrate that the overexpression of indoleamine 2,3-dioxygenase (IDO) restricts ATP production in CD8+ cells, whilst in vitro studies indicate this effect is mediated by reduced activity of electron transport chain complex I, which accounts for the decreased ATP production observed in infiltrating T cells (Liu et al., 2009)