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the present inventors recognize a solution to prevent in vivo target protein cleavage using split-inteins whose catalytic residues are split between two peptide chains: the N-terminal intein (IN) and the C-terminal intein (IC)

Primer pairs oriTF/oriTR, gr IF/ gr IR, and gr OF/ gr OR were used to confirm the deletion of gr

Suv ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, et al

Works through completely different mechanisms, adding a regenerative effect that complements standard treatments