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Finally, Bacteroidetes relative abundance was significantly increased in 5A-1MQ-treated mice switched from WD to LD relative to WD control mice (Fig

it works upstream, on an enzyme called nicotinamide N-methyltransferase (NNMT) that fat cells over-express when they become metabolically sluggish

Elevated NNMT expression has been observed in adipose tissue of animals with insulin resistance, and modulation of this enzyme has been shown to influence weight and metabolic function in preclinical models