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After two or more weeks without administration, restarting at the full maintenance dose risks severe gastrointestinal distress because receptor adaptation has partially reversed

In recent years, oxidative stress has been recognized as one of the main pathomechanisms of AD, since this phenomenon is closely related to some key events in neurodegeneration, such as mitochondrial dysfunction, inflammation, metal-induced toxicity, and protein misfolding (Nunomura and Perry 2020)

In the first stage, titles and abstracts of articles retrieved from databases such as PubMed and Google Scholar were screened

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Human umbilical vein endothelial cells (HUVECs) and normal human dermal fibroblast (NHDF) cells and media were purchased from Cambrex