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Del Bo et al., 2019

Altogether, these findings suggest a potential beneficial effect of vitamin B12 in reducing neuroinflammation and promoting neuroprotection in patients with persistent VCD long after experiencing mild acute COVID-19

By blocking NNMT, 5-amino-1MQ stimulates an increase in NAD+, a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)