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Li et al., demonstrated that depletion of SETD2 and/or H3K36me3 in cells resulted in an MMR-D mutator phenotype, providing a molecular explanation of tumors that are positive for MSI with the MMR-D phenotype [98]

In plastids, glutathione reductase (GR) safeguards a highly reduced glutathione pool relying on NADPH as electron source, whereas ferredoxin TRX reductase (FTR) draws electrons from photosynthetic light reactions to reduce TRX