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Several repurposed drugs are being evaluated in NSCLC: Metformin: This widely used antidiabetic drug inhibits mitochondrial complex I, reduces hepatic gluconeogenesis, and activates AMPK

These RBC enzyme disorders are due to abnormalities in the HMP shunt and glutathione metabolism, glycolytic enzyme deficiencies, and abnormalities in purine and pyrimidine metabolism

Thus, as the SLC1A5 variant is the only currently known glutamine transporter in the mitochondrial inner membrane 16 , targeting the SLC1A5 variant could be an effective strategy for selectively inhibiting glutamine metabolism in cancer cells (Fig