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Overview of the 21 ADCs Approved by FDA/PMDA/NMPA [2] Strategies for ADC Linker Cleavable Site Design Chemically Cleavable Linkers Early successes in ADC linker design often utilized pH-sensitive mechanisms

Furthermore, western blotting analysis revealed that oxalate stimulation upregulated the SOX4 protein level

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We collected clinical data at the timing of baseline, end of the treatment (EOT), 12 weeks after the EOT, 24 weeks after the EOT, 1 year after the EOT and every 1 year thereafter, which were examined at each hospital

Differential metabolites were then identified using the criteria of a fold change 1.2 or 0.83 and a p-value 1.42 and an adjusted p-value (Q-value) 0.05