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The intestine-specific knockout of Cldn7 initiates the colonic inflammation because of the increase of the paracellular flux of the bacterial products from the intestinal lumen to lamina propria, such as LPS, peptidoglycan and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (Tanaka et al., 2015)

Furthermore, with the rise of global e-commerce in herbal supplements, there is an urgent need for harmonization of regulatory frameworks and cross-border monitoring mechanisms to prevent the proliferation of substandard or counterfeit products

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