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0.9% is well within solubility) Antimicrobial spectrum : Effective against a broad range of bacteria, with activity attributed to membrane disruption at the lipid bilayer level Compatibility : Relatively non-reactive with most peptides and proteins at the 0.9% concentration used in BAC water Stability : Chemically stable in aqueous solution at ambient temperatures, with slow oxidation to benzaldehyde and benzoic acid over time The 0.9% concentration was established through decades of pharmaceutical practice as providing adequate microbial inhibition while remaining below levels associated with tissue irritation or systemic toxicity concerns in historical parenteral use

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To address this, investigators directly administered decanoic acid, without change of diet (Warren et al., 2020)

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Although current clinical studies have demonstrated a correlation between PPIs and cholelithiasis, the specific effect of PPI-induced changes in the intestinal flora on cholelithiasis remains unclear