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66 NavarroE.Gonzalez-LafuenteL.Perez-LiebanaI.BuendiaI.Lopez-BernardoE.Sanchez-RamosC.et al (2017)

For anti-aging and longevity optimization, the priority shifts from acute metabolic correction to long-term mitochondrial maintenance and senescence suppression

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In support of these results, treatment with 5-azacytidine (a DNMT inhibitor) reversed the AIE-induced increases in anxiety-like behaviors and alcohol consumption and normalized the methylation status of the Npy and Bdnf promoters