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When administered, the peptide preferentially accumulates in adipose tissue, where it interacts with beta-3 adrenergic receptors on fat cell membranes and initiates metabolic signaling cascades

Therefore, it was only a matter of time until STING agonists entered clinical trials, with DMXAA being the first

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In HeLa cells, mRNA containing all four modifications provided the highest target protein expression compared to natural RNA, likely due to the increased stability afforded by non-canonical analogues with substitutions at the 2 position of the ribose