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This activation is accompanied by vital methylation reactions that allow the synthesis of creatine and phosphatidylcholine and the methylation of DNA, RNA, and a large number of neuromediators

2.3.1 The relationship between ferroptosis and autophagy Appropriate autophagy has evolved into a pro-survival response for cells, but excessive autophagy, especially selective autophagy, and impaired lysosomal activity may promote cellular ferroptosis (92)

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For example, CNS is very sensitive to H 2 S poisoning due to the minimal level of H 2 S catabolizing capacity

Diabetes Aggravates Myocardial Ischaemia Reperfusion Injury via Activating Nox2-Related Programmed Cell Death in an AMPK-Dependent Manner