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For those diagnosed with Wernickes encephalopathy it is recommended to receive thiamine doses of 200 500mg three times daily for 3 5 days followed by oral thiamine doses ranging from 250 1000mg per day

As the dose climbs, the balance changes

In relation to cardiac activity, these may be bradycardia, prolongation of the QT interval and polymorphic ventricular tachycardia

Specifically, we treated in parallel groups of Tbx1 +/ mice with PBS (n = 14) or vB12 (n = 13) and compared them with a group of WT mice treated with PBS (n = 15) or vB12 (n = 18)