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TB-500 is a synthetic version of a 17-amino-acid fragment of thymosin beta-4 (TB4), one of the most-studied actin-sequestering proteins in cell-biology research

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Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]

Overexpression of zwf or gnd , two major enzymes of the PPP, could improve carbon flux flow (Sekar et al., 2017