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While preclinical studies have shown promising results, clinical trials have yielded inconsistent findings, due to suboptimal study design, results misinterpretation, and misleading conclusions

Pharmacology of Schisandra Chinensis Bail.: An Overview of Russian Research and Uses in Medicine. Journal of Ethnopharmacology 118.2 (2008): 183-212

Instead, more accurate evidence on misfolded wild-type SOD1 in ALS could be provided by immunoprecipitation (IP) from unfixed spinal cord homogenates with misfolded-SOD1 antibodies, which are summarized in Table 2

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The ability of mRNA and AdV vaccines to promote intracellular production of S protein along with innate immune responses should prime both CD8 + and CD4 + T cells to differentiate into effector and memory subsets