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Figure 1 2.1 Glutamine uptake and transport in cancer cells Glutamine uptake by cancer cells is mediated by transporters ( + )-dependent transmembrane transporter encoded by the solute carrier family 1 member 5 ( SLC1A5 ) gene, mediates the cellular uptake of glutamine and other neutral amino acids and is considered to be a primary glutamine transporter in cancer cells ( SLC7A5 gene, preferentially transports large branched and aromatic neutral amino acids, and its expression is upregulated in various types of cancer cells ( via LAT1 with high affinity ( SLC7A11 )

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