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It is worth noting that the accumulation of UGA codons in open reading frames for selenoproteins may refer to the existence of specific sequences within the untranslated mRNA region responsible for the insertion of selenocysteine (SeCys) in place of another cysteine amino acid (Cys) during the biosynthesis of various proteins

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The heterogeneity of cellular senescence: insights at the single-cell level

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This special design makes them very hydrophilic and helps to avoid unwanted interaction with mucus or proteins 182,183