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4 The proposed mechanism involves both direct neuroprotective effects (via eNOS-NO pathway preservation of vascular supply to injured nerve) and indirect effects via modulation of the inflammatory microenvironment at the injury site

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172,173 For example, acid-sensitive imine linker (DAK) was conjugated with D-T7 peptide on the nanoparticle surface, which would break up in acidic environment, facilitating the endo/lysosomal escape