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In summary, a defect in the methionine biosynthesis pathway at low pH renders the metZ strain metabolically less active, thereby inhibiting its growth at acidic pH

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Reyes Del Paso GA, Garcia-Hernandez A, Contreras-Merino AM, et al.A two-component model of hair cortisol concentration in fibromyalgia:Independent effects of pain chronicity and severity

Collectively, these studies describe a mechanism by which glutamine-derived nitrogen is essential for the rapid proliferation of cancer cells corresponding to an urgent need for nucleotide biosynthesis