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Additionally, a preclinical study using a rabbit TB model showed that bevacizumab inhibited neovascularization, enhanced drug penetration into granulomas, improved lung pathology, and increased oxygenation, suggesting its potential to enhance the effectiveness of the current TB regimens [37]

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Novel routes of drug delivery The therapeutic effect of a clinical condition is closely correlated with the administration route of a drug, and the efficacy of the same drug may vary greatly depending on the method of administration (Table 3) [132]

The genetic basis of myelodysplasia and its clinical relevance

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