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GLP-1 medications work predominantly on the brain and gastrointestinal tract

[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Klimova, N., Long, A

If you were to quit taking Phentermine abruptly, you would likely experience some rebound hunger and rebound fatigue, and there could be some weight gain associated with the termination of Phentermine

Indeed, evidence suggests that peripheral innate immune system molecules can trigger a secondary neuroinflammatory response in the central nervous system (CNS) 8,9,10