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Long-term elevated glucose levels in the body lead to the development of insulin resistance and subsequent hyperinsulinemia, which may lead to increased androgen synthesis by ovarian theca cells

Eckel, J

Neuropeptide signalling proteoforms derived from VGF, somatostatin (SST) and protachykinin-1 (TAC1) showed higher abundance in AD-resilient than AD-dementia brain, whereas signalling proteoforms of cholecystokinin (CCK) and chromogranin (CHG) A/B and multiple cytoskeletal molecules were enriched in frail vs control brain

revealed that females tend to develop AMS, 34 whereas others reported that men were slightly more affected by AMS than women

McCollom, T