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Addressing these questions will thus refine our understanding of the IFN-IChac2GSH signaling axis and strengthen its potential as a therapeutic target in inflammation-driven comorbidities

These studies can provide more therapeutic targets

Genetics 154, 847856

However, the percentage of these molecules is low, such that large amounts of glutathione need to be ingested in order for supplementation to have any meaningful effect

Based on the existing research evidence, future research should focus on clarifying the molecular mechanism by which gut microbial metabolites regulate lung macrophage polarization and developing targeted intervention strategies (such as MSC exosomes or specific miRNA preparations)