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meanwhile, the produced Fe 3+ was reduced by GSH into Fe 2+ , accompanying the generation of GSSG (Figures 3A, B)

Invest 134 , e175265 (2024)

In other cases, the reactive forms of oxygen (singlet oxygen, the superoxide and hydroxyl radicals, hydrogen peroxide), that are not coped with by the natural detoxifying mechanisms, can react with biological structures and impair their physiological function