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Xia et al., 2025d) Looking ahead, research should focus on validating tissue-specific biomarkers and integrating spatial metabolomics with artificial intelligence technology to refine treatment strategies ( Statements Author contributions H-HX: Visualization, Writing original draft, Writing review & editing

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Considering arginine has been recognized for its capacity to activate mTORC1 and persistent mTORC1 activation is a well-documented inducer event of cellular senescence, 22,23,24 we are interested to elucidate the relationship between glutaminolysis and mTORC1 activation, with particular attention to investigate if the senescence-associated reprogramming of glutaminolysis is connected with the senescence-associated persistent mTORC1 activation, i }\) norm(control) : The average value of the normalized consumption rate of the control

Between 1975 and 1979, they published a series of articles describing the isolation of a Streptomyces hygroscopicus strain from these soil samples, from which they extracted a compound with antifungal properties 1,2,13,14 and immunosuppressive potential