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Axonal damage: a key predictor of outcome in human CNS diseases

Reference: Staresinic M, Sebecic B, Patrlj L, et al

As a result, no body axis forms, normal patterning is not established, and the TrxR1-deficeint embryonic cells proliferate as a disorganized mass of primitive endoderm and ectoderm until, by E8.5, they have likely exceeded the volumetric constraints for survival without a functional (mesoderm-derived) cardiovascular and hematopoietic system