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Even though edavarone seems to be of value in neurological disorders, it has limited ability to cross the BBB

To resolve this energy crisis, under the regulation of multiple signaling pathways, including AMP-activated protein kinase, mechanistic target of rapamycin complex 1, sirtuins, peroxisome proliferator-activated receptor alpha, peroxisome proliferator-activated receptor- coactivator 1, and hypoxia-inducible factor-1 alpha, surviving PTCs may undergo a temporary shift toward glycolysis-dominant energy metabolism

Zhang, L., Zhang, G., Wang, Y., Zhou, Z., Meng, Y., and Chen, B., Effect of soil salinity on physiological characteristics of functional leaves of cotton plants, J

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