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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function

2017;63:e12438

A mixture containing reduced glutathion and at least one thiol-derivative of glutathion from the group methyl-glutathionyl-(thio)-ether ethyl-glutathionyl-(thio)-ether mono-acetyl-glutathionyl-(thio)-ester mono-phosphoric acid-glutathionyl-(thio)-ester and at least one anthocyan compound from the group pelargonidine peonidine cyanidine malvidine petunidine delphinidine for the therapeutic treatment of the human or animal body

Increased levels of Irisin (1 mg/kg/day, 5 days/week, 2 weeks) could significantly mitigate ROS accumulation, dysregulation of autophagy, NF-B-Snail pathway activation, and the phenotype of endothelial-to-mesenchymal transition through targeting UCP2 in a mouse DIC model [140]

Variability in study designs and patient cohortsoften excluding early-stage CKD or non-dialysis populationsfurther obscures the generalizability of findings (121)