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Accumulated plasma levels at steady state are 2.2 to 2.5 times higher than concentrations produced by a single dose, per FDA pharmacokinetic data

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The transmitters released during synaptic activity are transported back to astrocytes, where a fraction (25%) is degraded with the remainder released and reused by the neurons

Shen BH , Dobie AC , Shusterman SL , Duzgol M, Homer-Bouthiette C , Kearney LE , Newman J , Pang B , Shankar DA , Zhang J , Gillmeyer KR , Bosch NA , Law AC