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Description

Psoriatic skin lesions contain high numbers of CD4 + T cells that produce IL-17, indicating that Th17 cells play a crucial role in the immunopathogenesis of psoriasis (Fujishima et al

Ferroptosis regulates lipid peroxidation via the GPX4/acyl-CoA synthetase long chain family member 4 axis, and targeting of GSH metabolism selectively eliminates resistant subpopulations that are dependent on antioxidant defenses

Mechanistic insights were derived from transcriptomics and lipid peroxidation assays

da Silva-Arajo ER, Manhes-de-Castro R, Pontes PB et al (2023) Effects of riboflavin in the treatment of brain damage caused by oxygen deprivation: an integrative systematic review

The gap between the gene expression research (which suggests systemic biological effects) and the actual human evidence (which is limited to topical skin endpoints) is substantial