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RNA interference-mediated knockdown of -synuclein protects human dopaminergic neuroblastoma cells from MPP+ toxicity and reduces dopamine transport

Precursor range was defined to m/z 400-1000 with equal windows sizes of 26 Th (including 1 Th overlap) using two steps each PASEF scan and cycle time of 100 ms locked to 100% duty cycle

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The peptide's small molecular weight (0.39 kDa) enables it to interact directly with DNA and act as an epigenetic regulatory factor, modulating chromatin structure and gene accessibility in neural tissue

GPx4 prevents atherogenesis by impairing lipid peroxidation and the sensitivity of vascular cell to oxidized lipids [87]