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Nevertheless, IDO1, the first rate-limiting enzyme in kynurenine metabolism, is upregulated in murine BMDMs upon infection with M.avium , however, its deficiency does not impact on the outcome of the infection (93)

The following reactions describe the removal of hydrogen peroxide and hydroperoxides catalyzed by GPx: In addition to catalase and glutathione peroxidases (GPXs), a family of six isoforms of peroxiredoxins (PRDX16) also reduce H 2 O 2 to O 2