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Description

At the cellular level, hypoxia correlates with a switch to aerobic (glycolytic) respiration with alteration of normal oxidative phosphorylation and mitochondrial function due to reduced activity of complex IIV and complex V of electron transport chain

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Immunohistochemistry with SOX10 (staining the cell nuclei of melanocytes) facilitates diagnosis of lentigo maligna, in this case showing an increased number of melanocytes along stratum basale of the skin, and nuclear pleomorphism