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In animals, unlike the deletion of Slc7a11 , the deletion of the GGT family member Ggt1 results in increased GSH levels in urine, reduced cysteine levels in tissues and perinatal lethality 24

Ethics declarations Competing interests The authors declare no conflict of interest

10.1056/NEJMe1802169 188

Accreditation Statement Pharmacists and Pharmacy Technicians are eligible to participate in this knowledge-based activity and will receive up to 1.0 CE Hours (or 0.1 CEUs) for completing the activity ACPE UAN 0009-0000-23-044-H05-P , passing the quiz with a grade of 70% or better, and completing an online evaluation

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved