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False negatives, meaning the test misses an actual infection, can happen when pathogen levels are too low to detect, due to sampling or lab issues, or if the causative agent is not included in the testing panel

Barde YA, Edgar D, Thoenen H

For example, spermidine/spermine N1-acetyltransferase 1 ( SAT1 ), a tumor protein p53 (TP53) target gene, mediates the expression of ALOX15 (but not ALOX5 and ALOX12) and is involved in TP53-mediated ferroptosis in H1299 cells

Karlin, 2011)

Severe forms of congenital or acquired airway flaccidity are troublesome pathologies that are difficult to treat with a mortality as high as 80%.[103] Supportive care with a tracheostomy or positive airway pressure may be insufficient and there may not be good surgical options, including anterior or posterior pexying of the airway.[104][105][106] Internal airway stenting carries a significant risk of device migration and airway obstruction or formation of granulation tissue.[107][108] Resorbable internal stents require careful surveillance due to short resorption time and possible device migration.[109][110][111] External splints using polytetrafluorethylene (PTFE) prostheses have significant risks of death, restenosis, and airway perforation.[99][100] 3D-printed tracheal splints using resorbable polycaprolactone (PCL) have had good success in patients with severe tracheobronchomalacia at high risk of death or permanent disability