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This allows homotaurine to act as an agonist of the GABAA receptor, exerting inhibitory effects on the central nervous system (CNS)

However, the studies are often short in duration, involve small sample sizes, or use inconsistent outcome measures, making it difficult to draw firm conclusions

5 Impaired neurogenesis and synaptic plasticity The hippocampus is a critical brain region for learning and memory, and particularly vulnerable to paclitaxel-induced toxicity (Murillo et al., 2023)

Mitochondrial dysfunction can also be a result of oxidative stress occurring in neurons, microglia, and astrocytes [6,26,28,30]

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