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These factors not only exacerbate local chronic inflammation within adipose tissue but also act via systemic circulation on peripheral tissues, including the liver and skeletal muscle, further inhibiting the insulin signaling pathway and aggravating IR (113, 114)

Since the main function of L-carnitine is to promote the -oxidation of long-chain fatty acids, this activity may increase lipocatabolic metabolism, thus increasing the cholesterol and triglyceride levels

Institutional Animal Care and Use Committee (IACUC) approval was therefore not necessary

n = 5): Rats in this group were given a daily dose of 200 mg/kg