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A broad overview of the science behind growth-hormone-derived peptides is available through the National Center for Biotechnology Informations library of peer-reviewed research on peptide fragments and metabolic signaling, which underscores how preliminary much of this work remains

Grey market peptides are sold online or through non-medical channels as research grade compounds, labeled not for human consumption, and marketed for weight loss or muscle building

These signaling cascades produce tissue-specific effects: hepatic IGF-1 production for endocrine growth signaling, muscle protein synthesis and glucose uptake, adipose tissue lipolysis, bone formation, and immune cell modulation

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This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function