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However, all the patients could persistently maintain normal TSH and FT 4 levels upon hormone replacement therapy, although they did have various complications due to late diagnosis and delayed treatment initiation (19.7 4.72 months) (Table 1)

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Importantly, hydrogen selenide and its activated form selenophosphate and other reactive low molecular mass (LMM) chemical species of Se are thought to be relevant to the majority of Se biological activity being metabolic precursors of selenoproteins (Loef et al., 2011