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The mechanisms that implicate the declining of age-related ascorbate are complex and involve multiple cell signaling pathways such as accelerated turnover, increased usage, reduced cellular uptake, and decreased absorption/reabsorption

Therefore whether the process of ferroptosis regulation, even its intervention efficiency in clinical practice, is impervious to this heterogeneity should also be considered in future studies

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Effect of FE extract (100mg/kg) on Serum Lipid Profile in Rats Treated with CdCl 2 As shown in Table 8, various treatments exerted adverse effects on the lipid profile

Evidence remains limited and more robust studies are required