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A 2023 randomised study of 214 adults found only 0.9 lbs additional loss after three months compared to placebo not statistically significant

Study population LARC within 12 cm from anal verge MRI-confirmed uninvolved MRF Median follow-up 48 months Treatment strategy CAPOX x4 cycles surgery Pelvic RT + capecitabine surgery Key 3-year outcomes LRRFS 97.4% (CRT) vs 96.3% (CAPOX) | HR 1.40 DFS 89.2% vs 87.9% | HR 0.88 OS 95.0% vs 94.1% | HR 0.86 Long-term toxicity matters Grade 2-4 late AEs 26.3% (CRT) vs 16.0% (CAPOX) Chronic proctitis 41.7% vs 33.6% Clinical interpretation Non-inferiority was not formally met due to extremely low event rates

If your stack is starting to feel like it's working against you, that's the moment to take stock

Recommended Code Progression Path Think of the ICD-10 for left shoulder pain as a code that should evolve alongside the clinical picture

Some therapies do require a consultation and, in certain cases, lab work to ensure everything is safe and appropriate