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Typically, this step will happen in one of two ways

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Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I (2008) IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung

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Histopathological examinations Brain and cerebellum tissue samples were fixed in 10% buffered formaldehyde for 48 h