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Looking ahead, 2 directions of work can be advanced based on this research: on one hand, establishing a multi-omics database for AS that integrates multi-center clinical data (including risk factors, imaging findings, and prognosis) with multi-dimensional omics data, while unifying quality control standards and ensuring data security to lay a foundation for optimizing diagnostic models

Iron is incorporated into cells mainly by TFR1-mediated system and is then safely stored in ferritin nanocages or present in the form of the labile iron pool that can promote lipid peroxidation [78]

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