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In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]

The effects of catechol-O-methyltransferase Inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells

Here we develop a self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and H 2 O 2 elimination on the basis of UOx and sodium citrate loading in amine functionalized hollow mesoporous silica nanoparticles (AHMSNs)

[115] Other cobalamin-requiring methyltransferase enzymes are also known in bacteria, such as Me-H 4 -MPT, coenzyme M methyltransferase

Currently, several pharmaceutical companies are investigating specific SIRT1 activators in Phase I and Phase II trials for the treatment of type II diabetes and obesity (228) to define their utility in the treatment of obesity and metabolic diseases