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GY: Conceptualization, Project administration, Writing review & editing, Methodology, Supervision

In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration

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6.3 Critical assessment and challenges of SSP-targeted therapy 6.3.1 Target specificity and toxicity evaluation in normal tissues The SSP is not only aberrantly activated in tumor cells but also participates in fundamental metabolism in normal tissues, including the nervous system, immune cells and the liver

Unpublished literature was also considered in this review through a search of the International Clinical Trials Registry Platform, the International Standard Registered Clinical/Social Study Number, and ClinicalTrials.gov